High-Energy Phosphate Metabolism of Isolated Coronary Arteries in the Dog
| Autor: | Makie Higuchi, Fumio Takenaka, Matao Sakanashi |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
High-energy phosphate
medicine.medical_specialty Vascular smooth muscle Phosphocreatine Physiology Isometric exercise Creatine chemistry.chemical_compound Adenosine Triphosphate Dogs Internal medicine medicine Animals Hypoxia Muscle Smooth Arteries Metabolism Phosphate Coronary Vessels Endocrinology Biochemistry chemistry Anaerobic glycolysis Cardiology and Cardiovascular Medicine Adenosine triphosphate Muscle Contraction |
| Zdroj: | Journal of Vascular Research. 15:190-197 |
| ISSN: | 1423-0135 1018-1172 |
| DOI: | 10.1159/000158165 |
| Popis: | The correlation between phosphate metabolism and isometric contraction was investigated in helical strips from dog coronary artery. Adenosine triphosphate (ATP) and creatine phosphate (CP) contents of resting strips did not significantly change during anoxia. ATP content remained unchanged during potassium-contracture under aerobic conditions but was significantly reduced by anoxia. Pre-treatment with iodoacetate resulted in a striking reduction in ATP content with a less marked decrease in CP content. ATP-depleting effect of iodoacetate was reduced slightly by the addition of pyruvate, but contractile response was not restored. It is considered that high-energy phosphates provided by anaerobic glycolysis can meet the energy requirements of resting coronary vessels but are insufficient for maintaining active tension. In resting strips equilibrated for 2 h in oxygenated bath solution, the reactivity to KC1 and anoxia appears to be dependent on the availability of ATP. |
| Databáze: | OpenAIRE |
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