Current status of cancer care for young patients with nasopharyngeal carcinoma in Jakarta, Indonesia

Autor: Jaap M. Middeldorp, I. Bing Tan, Renske Fles, Sharon D. Stoker, Djayadiman Gatot, Lisnawati Rachmadi, Marlinda Adham, Maarten A. Wildeman, Djumhana Atmakusumah, Soehartati Gondhowiardjo, Astrid E. Greijer, Bambang Hermani
Přispěvatelé: Maxillofacial Surgery (AMC), MKA AMC (OII, ACTA), Faculteit der Geneeskunde, Pathology, CCA - Innovative therapy, Ear, Nose and Throat, Oral and Maxillofacial Surgery
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Pediatrics
medicine.medical_treatment
Cancer Treatment
lcsh:Medicine
Tertiary Care Centers
Basic Cancer Research
Medicine and Health Sciences
Young adult
Stage (cooking)
Child
lcsh:Science
Multidisciplinary
Nasopharyngeal Carcinoma
Treatment Outcome
Oncology
Child
Preschool
Pediatric Otolaryngology
Female
Research Article
Adult
medicine.medical_specialty
Adolescent
Nasopharyngeal neoplasm
Young Adult
SDG 3 - Good Health and Well-being
medicine
Humans
Survival analysis
Neoplasm Staging
Chemotherapy
business.industry
Carcinoma
lcsh:R
Cancer
Nasopharyngeal Neoplasms
medicine.disease
Survival Analysis
Surgery
Radiation therapy
Health Care
Nasopharyngeal carcinoma
Otorhinolaryngology
Head and Neck Cancers
Indonesia
Pediatric Oncology
lcsh:Q
Patient Care
Clinical Medicine
business
Follow-Up Studies
Zdroj: PLoS ONE, 9(7). Public Library of Science
Adham, M, Stoker, S D, Wildeman, M A, Rachmadi, L, Gondhowiardjo, S, Atmakusumah, D, Gatot, D, Fles, R, Greijer, A E, Hermani, B, Middeldorp, J M & Tan, I B 2014, ' Current status of cancer care for young patients with nasopharyngeal carcinoma in Jakarta, Indonesia ', PLoS ONE, vol. 9, no. 7, pp. e102353 . https://doi.org/10.1371/journal.pone.0102353
PLoS ONE, Vol 9, Iss 7, p e102353 (2014)
PLoS ONE
PLoS ONE, 9(7):e102353. Public Library of Science
Adham, M, Stoker, S D, Wildeman, M A, Rachmadi, L, Gondhowiardjo, S, Atmakusumah, D, Gatot, D, Fles, R, Greijer, A E, Hermani, B, Middeldorp, J M & Tan, I B 2014, ' Current status of cancer care for young patients with nasopharyngeal carcinoma in jakarta, indonesia ', PLoS ONE, vol. 9, no. 7, e102353 . https://doi.org/10.1371/journal.pone.0102353
ISSN: 1932-6203
Popis: BackgroundNasopharyngeal carcinoma (NPC) is endemic in Indonesia and 20% of the patients are diagnosed before the age of 31. This study evaluates presentation and treatment outcome of young patients in Jakarta, in a tertiary referral centre.MethodsForty-nine patients under the age of 31, diagnosed with NPC between July 2004 and January 2007, were evaluated. Baseline data included histological type, stage of disease and presenting symptoms. We intended to follow all patients after diagnosis to reveal treatment outcome and overall survival (OS).ResultsAll but two patients had advanced stage disease (94%), 7 (14%) had distant metastasis. The median interval between start of complaints and diagnosis was 9 months. Forty-two patients were planned for curative intent treatment. Eleven patients (26%) never started treatment, 2 patients did not complete treatment and 3 patients did not return after finishing treatment. Four patients died before radiation could start. Three patients died within 4 months after treatment. Nine patients (21%) had a complete response. Due to the high number of patients who were lost to follow-up (LFU), OS was analyzed as follows: a best-case (patients censored at last contact) and a worst-case scenario (assuming that patients who did not finish treatment or had disease at last contact would have died). The 2-year OS for patients without distant metastases was 39-71%.ConclusionTreatment outcome for young patients with NPC in this institute was poor. Improvement can be achieved when NPC is diagnosed at an earlier stage and when there is better treatment compliance.
Databáze: OpenAIRE
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