Efficacy and Safety of Disinfectants for Decontamination of N95 and SN95 Filtering Facepiece Respirators: A Systematic Review

Autor: Rhiannon Ng, Jess Gibson, Margaret Sampson, Anne Tsampalieros, Katie O’Hearn, James Dayre McNally, Shira Gertsman, Lindsey Sikora, Richard Webster
Rok vydání: 2020
Předmět:
EtO
Ethylene oxide
business.product_category
Sodium Hypochlorite
Disinfectant
H2O2
Hydrogen peroxide
030501 epidemiology
FFR
FFR
Filtering facepiece respirator
Respiratory Protective Devices
VSV
Vesicular Stomatitis Virus (VSV)
Respirator
Decontamination
0303 health sciences
SD
Standard Deviation
General Medicine
Human decontamination
Infectious Diseases
PPE
Vaporized hydrogen peroxide
Medical emergency
Coronavirus Infections
0305 other medical science
Microbiology (medical)
Ultraviolet Rays
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
CDC
Centres for Disease Control and Prevention
Guidelines as Topic
Original research
Article
03 medical and health sciences
NIOSH
The National Institute of Health and Safety
Equipment Reuse
medicine
Humans
PPE
Personal protective equipment
Personal protective equipment
Single cycle
UVGI
Ultraviolet germicidal irradiation
Pandemic
030306 microbiology
business.industry
N95
COVID-19
Hydrogen Peroxide
medicine.disease
FDA
U.S. Food and Drug Administration
SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus 2
OSHA
Occupational Safety and Health Administration
business
Disinfectants
Zdroj: The Journal of Hospital Infection
Journal of Hospital Infection
DOI: 10.31219/osf.io/ct6m8
Popis: Background: Decontaminating and re-using filtering facepiece respirators (FFR) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic.Aim: The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFR. Methods: We conducted a systematic review on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted and verified predefined data fields. Original research reporting on N95 FFR function, decontamination, physical appearance, safety, or mask fit following decontamination with a disinfectant was included. Findings and Conclusions: A single cycle of vaporized hydrogen peroxide successfully removes infectious pathogens without affecting mask function or fit, and with little change in FFR physical appearance. Residual hydrogen peroxide levels following decontamination were below the safety limit. More than one decontamination cycle of vaporized hydrogen peroxide may be possible but further information is required on how multiple cycles would affect mask fit in a real world setting before the upper limit can be established. Although immersion in liquid hydrogen peroxide does not appear to adversely affect mask function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on mask fit. Sodium hypochlorite, ethanol, isopropyl alcohol and EtO are not recommended due to safety concerns or negative effects on mask function.
Databáze: OpenAIRE
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