Nitric Oxide and the Regulation of Apoptosis in Tumour Cells
| Autor: | Paul Eggleton, Paul G. Winyard, Joanna M. Tarr |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Programmed cell death
Apoptosis Mitochondrion Nitric Oxide Nitric oxide chemistry.chemical_compound Neoplasms Heat shock protein Drug Discovery Animals Humans Heat-Shock Proteins Caspase Cell Proliferation Pharmacology Neovascularization Pathologic biology Matrix Metalloproteinases Mitochondria Nitric oxide synthase Cell Transformation Neoplastic Proto-Oncogene Proteins c-bcl-2 Biochemistry chemistry Caspases biology.protein Nitric Oxide Synthase Tumor Suppressor Protein p53 Signal transduction Signal Transduction |
| Zdroj: | ResearcherID |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/138161206779010477 |
| Popis: | Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined. |
| Databáze: | OpenAIRE |
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