Measurement of airway inflammation in current smokers by positron emission tomography
| Autor: | Lars Edenbrandt, Sandra Diaz, Per Wollmer, Sabine Garpered, Sven Valind, David Minarik |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Physiology Inflammation Systemic inflammation Fluorodeoxyglucose F18 Predictive Value of Tests Physiology (medical) Positron Emission Tomography Computed Tomography medicine Humans Tissue Distribution Prospective Studies Lung cancer Lung Aged COPD Smokers medicine.diagnostic_test business.industry Smoking Cancer Reproducibility of Results General Medicine Pneumonia respiratory system Middle Aged medicine.disease respiratory tract diseases Peripheral Positron emission tomography Female medicine.symptom Radiopharmaceuticals Airway business |
| Zdroj: | Clinical physiology and functional imagingReferences. 39(6) |
| ISSN: | 1475-097X |
| Popis: | BACKGROUND Accumulation of activated neutrophilic leucocytes is known to increase uptake of 18 F-fluorodeoxyglucose (18 F-FDG) into lung tissue. Available evidence suggests that smokers and subjects with chronic obstructive pulmonary disease (COPD) have neutrophilic inflammation in peripheral airways. The aim of this study was to examine whether current smokers have higher lung tissue uptake of 18 F-FDG than never-smokers when correcting for air fraction of the lungs. METHODS We prospectively recruited 33 current smokers and 33 never-smokers among subjects referred for diagnosis or staging of cancer, other than lung cancer, with combined positron emission tomography/computed tomography (PET/CT) with 18 F-FDG. Subjects with focal 18 F-FDG uptake or focal CT abnormalities in the lungs were excluded. The lungs were segmented in the CT image, and lung density measured. 18 F-FDG uptake was measured in the corresponding volume and corrected for air fraction. RESULTS Lung uptake of 18 F-FDG, corrected for air fraction, was 12·5 and 8 per cent higher in the right and left lungs, respectively, in current smokers than in never-smokers (P |
| Databáze: | OpenAIRE |
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