Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update
| Autor: | Sadie M.E. Swainson, Ioanna Danai Styliari, Martin C. Garnett, Vincenzo Taresco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
polymeric platforms 02 engineering and technology Review Gene delivery 010402 general chemistry 01 natural sciences lcsh:QD241-441 lcsh:Organic chemistry Adipate Amphiphile lipase Chemistry Biomaterial General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Polyester Polymerization poly(glycerol adipate) Drug delivery Surface modification functionalization biodegradable 0210 nano-technology |
| Zdroj: | Polymers, Vol 11, Iss 10, p 1561 (2019) Polymers |
| ISSN: | 2073-4360 |
| Popis: | The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature. |
| Databáze: | OpenAIRE |
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