Induction of micronuclei and nuclear abnormalities by cyclophosphamide and colchicine in Xenotoca melanosoma (Pisces, Goodeidae) from Lake La Alberca in Michoacan, Mexico
| Autor: | Tetsuya Ogura, Guillermo Moisés Zúñiga-González, José Luis Zavala-Aguirre, Héctor René Buelna-Osben, María Luisa Ramos-Ibarra, Lola Paulina Flores-Kehn, Olivia Torres-Bugarín |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Environmental Engineering Cyclophosphamide Erythroblasts Zoology Fresh Water medicine.disease_cause chemistry.chemical_compound Cyprinodontiformes medicine Colchicine Animals Mexico Micronuclei Chromosome-Defective Goodeidae Cell Nucleus Micronucleus Tests biology Dose-Response Relationship Drug Ecology Aquatic animal General Medicine biology.organism_classification Aneugens chemistry Micronucleus test Xenotoca melanosoma Female Bioindicator Genotoxicity medicine.drug Environmental Monitoring Mutagens |
| Zdroj: | Journal of environmental science and health. Part A, Toxic/hazardous substancesenvironmental engineering. 45(1) |
| ISSN: | 1532-4117 |
| Popis: | This study is a follow-up of previous research in which we described the frequency of spontaneous micronucleated erythrocytes (MNE) in the Goodeid Xenotocoa melanosoma collected from Lake La Alberca, located in the state of Michoacan, Mexico. In the present work, we measured micronuclei (MN) and nuclear abnormalities (NA) in erythrocytes of peripheral blood. Bioassays taken at 24 or 96 hours in either the cyclophosfamide (CP) or colchicine (COL) showed a significant increase in MN and BC (P values ranging from 0.0499 to 0.0036) compared with information from wild organisms collected over 3 years. Concentrationdependent and time-dependent responses support the proposal of using endemic Xenotoca melanosoma as a bioindicator of genotoxicity and cytotoxicity with a high transcendence for the health of the entire ecosystem and evaluation of the Lerma-Chapala watershed. |
| Databáze: | OpenAIRE |
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