Monthly brain magnetic resonance imaging scans in patients with clinically isolated syndrome
| Autor: | G. L. Lenzi, S. Di Legge, Maria Cristina Piattella, Patrizio Pasqualetti, Francesca Caramia, Patrizia Pantano, I. Pestalozza, Carlo Pozzilli |
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| Rok vydání: | 2005 |
| Předmět: |
Multiple Sclerosis
Time Factors Gadolinium chemistry.chemical_element Diagnosis Differential Lesion Central nervous system disease 03 medical and health sciences 0302 clinical medicine Humans Medicine Brain magnetic resonance imaging In patient 030212 general & internal medicine mri clinically isolated syndrome enhancing lesions multiple sclerosis triple dose of gadolinium Clinically isolated syndrome medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging Syndrome medicine.disease Magnetic Resonance Imaging Neurology chemistry Disease Progression Neurology (clinical) medicine.symptom business Nuclear medicine 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Multiple Sclerosis Journal. 11:390-394 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1191/1352458505ms1175oa |
| Popis: | We investigated if monthly gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) can assist the clinician in anticipating the diagnosis of multiple sclerosis (MS) in the very first few months following a clinically isolated syndrome (CIS). A consecutive series of CIS patients with ≥ 3 T2-weighted (T2W) hyperintense brain MRI lesions suggestive of MS were followed up for the first six consecutive months after enrollment with monthly triple-dose Gd-enhanced brain MRI scan. MRI conversion to MS was defined by the presence of either ≥ 1 new Gd-enhancing lesion or ≥ 1 new T2W lesions in the subsequent MRI scan. Sixty patients were included. Of them, 30 (50%) had at least one Gd-enhancing lesion on the baseline MRI scan. After three months, MRI conversion to MS was observed in 80% and 62% of patients based on the appearance of ≥ 1 new T2 lesion and ≥ 1 new Gd-enhancing lesions, respectively. The presence of ≥ 1 new T2W lesion was observed in 90% and 82% of patients who had, at baseline, a Gd-positive MRI scan and dissemination in space based on the new McDonald’s criteria, respectively. The rate of MRI conversion remained almost stable in the last two MRI scans. Our study suggests that the majority of CIS patients with an abnormal baseline scan showed an MRI conversion to MS after three months. The model of six months as the optimal interval for repeating MRI exam is not supported by the present data. |
| Databáze: | OpenAIRE |
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