Coronavirus antigens as targets of antibody responses
| Autor: | Tal Gilboa, Chi-An Cheng, Augusta Uwamanzu-Nna, Roey Lazarovits, Alana F. Ogata, David R. Walt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
SARS-CoV-2
viruses Biochemistry (medical) Clinical Biochemistry fungi COVID-19 antigen-antibody responses Biology biochemical phenomena metabolism and nutrition medicine.disease_cause Antibodies Viral Virology Article Immunity Humoral body regions Antibody response Antigen humoral immunity Antibody Formation medicine Humans Child skin and connective tissue diseases coronavirus antigens Coronavirus |
| Zdroj: | Clinics in Laboratory Medicine |
| ISSN: | 1557-9832 0272-2712 |
| Popis: | Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection. |
| Databáze: | OpenAIRE |
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