Development of pemphigus foliaceus in a mucous membrane pemphigoid patient: An insight into possible mechanism eliciting a distinct autoimmune bullous disease in a rare anti-basement membrane autoimmunity
| Autor: | Manabu Ohyama, Yurie Shimoda-Komatsu, Yoshimi Yamazaki, Kanae Fukui |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Exacerbation Erythema Mucocutaneous zone Pemphigoid Benign Mucous Membrane Azathioprine Autoimmunity Dermatology medicine.disease_cause Autoantigens Serology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Pemphigoid Bullous medicine Humans Pemphigus foliaceus Aged Autoantibodies Mucous Membrane business.industry Autoantibody General Medicine medicine.disease 030220 oncology & carcinogenesis medicine.symptom business Pemphigus medicine.drug |
| Zdroj: | The Journal of dermatologyREFERENCES. 48(5) |
| ISSN: | 1346-8138 |
| Popis: | Mucous membrane pemphigoid (MMP) rarely coexists with another autoimmune bullous disease (AIBD). Herein, we report an extremely rare MMP case who sequentially developed pemphigus foliaceus (PF). A 72-year-old man had been treated by azathioprine monotherapy for anti-BP180 MMP for 1.5 years. Clinical findings suggestive of PF, represented by scaly erythema and erosions, started to appear approximately 1 month after the episode of diarrhea. Serological and immunohistochemical examinations confirmed the diagnosis of PF. The mucocutaneous lesions were controlled by oral azathioprine and topical corticosteroids. To our knowledge, this is a previously unreported case of PF coexistent with MMP. A literature review of MMP cases associated with AIBD elucidated that 16 out of 18 cases simultaneously developed MMP and AIBD, while only two cases were diagnosed sequentially by the changes in clinical symptoms similar to our case. The titer of anti-desmoglein 1 antibodies lineally correlated with the changes in the severity of scaly erythema. Mild but noticeable exacerbation of mucosal erosion prior to the gradual increase in anti-BP180-NC16a antibodies was also noted. Unlike in other cases where MMP/AIBD coexisted, sequential development of autoantibodies in our case cannot be explained by the epitope-spreading theory as autoantigens are micro-anatomically isolated from one other. The preceding viral infection and/or continuous moderate inflammation due to azathioprine monotherapy for MMP might have contributed to the development of PF in our case. |
| Databáze: | OpenAIRE |
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