Prevalence of human papillomavirus in benign and malignant laryngeal lesions in Egyptian patients: Cross-sectional study
| Autor: | H Kassamy, S Abuelela, Ramy M. Salem, P Milad, A Askoura, Dina Ragab |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Larynx medicine.medical_specialty Cross-sectional study Biopsy Polymerase Chain Reaction law.invention 03 medical and health sciences 0302 clinical medicine law Prevalence medicine Humans Papillomaviridae Human papillomavirus Laryngeal Neoplasms Polymerase chain reaction Aged biology medicine.diagnostic_test business.industry Papillomavirus Infections Laryngeal lesion Middle Aged Laryngeal Neoplasm biology.organism_classification Dermatology Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis DNA Viral Carcinoma Squamous Cell Egypt Female business |
| Zdroj: | Clinical Otolaryngology. 43:312-316 |
| ISSN: | 1749-4478 |
| DOI: | 10.1111/coa.12979 |
| Popis: | OBJECTIVE To assess the prevalence of human papillomavirus (HPV) in benign and malignant laryngeal lesions among Egyptian patients. DESIGN Observational analytical cross-sectional study. SETTING Ain Shams University hospital, Otorhinolaryngology department PARTICIPANTS: Formalin-fixed paraffin-embedded specimens of 126 patients (70 benign laryngeal lesions and 56 squamous cell carcinoma lesions) were assessed for the presence of HPV DNA using MY09/11 PCR-based DNA detection. MAIN OUTCOME MEASURES Percentage of positive samples was calculated. RESULTS All 70 benign laryngeal lesion specimens were negative for the HPV DNA, while 2 of the 56 squamous cell carcinoma lesions (3.6%) were positive. CONCLUSIONS The presence of HPV DNA in only two specimens in our study suggests that the proportion of laryngeal squamous cell carcinomas attributable to infection by HPV seems to be very low in Egypt. |
| Databáze: | OpenAIRE |
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