Cutaneous and renal vasodilatory response to local pressure application: A comparative study in mice

Autor: Audrey Josset-Lamaugarny, Anne-Laure Begey, Kiao Ling Liu, Ming Lo, Nicolas Picard, Bérengère Fromy, Laurence Dubourg, Catherine Gauthier, Dominique Sigaudo-Roussel
Přispěvatelé: Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305 (LBTI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Pharmaceutiques et Biologiques (ISPB), Université de Lyon-Université de Lyon, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Université de Lyon, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Time Factors
[SDV]Life Sciences [q-bio]
Laser Doppler flux
Human skin
Vasodilation
Stimulation
030204 cardiovascular system & hematology
Kidney
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Laser-Doppler Flowmetry
Skin
integumentary system
Adaptation
Physiological
medicine.anatomical_structure
Anesthesia
Cardiology and Cardiovascular Medicine
Blood Flow Velocity
Transient receptor potential vanilloid type 1
medicine.medical_specialty
Calcitonin Gene-Related Peptide
Renal cortex
TRPV Cation Channels
Nitric Oxide
Renal Circulation
Microcirculation
Nitric oxide
03 medical and health sciences
Internal medicine
Pressure
medicine
Animals
Sodium Chloride
Dietary
Endothelium dysfunction
business.industry
Cell Biology
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
Regional Blood Flow
Calcitonin
Microvessels
Prostaglandins
Endothelium
Vascular
business
Pressure-induced vasodilation
Zdroj: Microvascular Research
Microvascular Research, Elsevier, 2018, 115, pp.44-51. ⟨10.1016/j.mvr.2017.08.007⟩
ISSN: 0026-2862
1095-9319
DOI: 10.1016/j.mvr.2017.08.007⟩
Popis: Background and aim We have reported a novel relationship involving mechanical stimulation and vasodilation in rodent and human skin, referred to as pressure-induced vasodilation (PIV). It is unknown whether this mechanism exists in kidney and reflects the microcirculation in deep organs. Therefore, we compared the skin and kidney PIV to determine whether their changes were similar. Methods In anesthetized mice fed a normal salt-diet, laser Doppler flux (LDF) signals were measured when an increase in local pressure was applied to the surface of the head skin with the rate of 2.2 Pa/s (1 mm Hg/min) and to the left kidney with a rate of 4.4 Pa/s (2 mm Hg/min). The mechanism underlying renal PIV was also investigated. The skin and kidney PIV were also compared during salt load (4% NaCl diet). Results The kidney had higher baseline LDF and vascular conductance compared to those of the skin. Pressure application increased the LDF in the kidney as well as in the skin with a comparable maximal magnitude (about 25% from baseline value), despite different kinetics of PIV evolution. As we previously reported in the skin, the kidney PIV response was mediated by the activation of transient receptor potential vanilloid type 1 channels, the release of calcitonin gene-related peptide, and the participation of prostaglandins and nitric oxide. In the absence of hypertension, high salt intake abolished the cutaneous PIV response and markedly impaired the renal one. Conclusion PIV response in the mouse kidney results from a neuro-vascular interaction. Despite some differences between the skin and the kidney PIV, the similarities in their response and signaling mechanisms suggest that the cutaneous microcirculation could reflect, in part, the microcirculation of the renal cortex.
Databáze: OpenAIRE
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