Fixed-Gap Tunnel Junction for Reading DNA Nucleotides
| Autor: | Jialing Yang, Quan Qing, Yann Astier, Robert J. Nemanich, Peiming Zhang, Venkatachalapathy S. K. Balagurusamy, Stuart Lindsay, Brian Ashcroft, Gustavo Stolovitzky, Sovan Biswas, Kathleen B. Reuter, Pei Pang, Jingwei Bai, Weisi Song, Joshua T. Smith |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Silicon
Analytical chemistry General Physics and Astronomy Molecular physics Article chemical recognition tunnel junction Atomic layer deposition Tunnel junction Microscopy Scanning Tunneling Molecule General Materials Science Nucleotide DNA sequencing Reactive-ion etching Electrodes Quantum tunnelling chemistry.chemical_classification Chemistry recognition tunneling Nucleotides General Engineering Electric Conductivity Conductance Hydrogen Bonding DNA Microfluidic Analytical Techniques Electrode Palladium |
| Zdroj: | ACS Nano ACS nano |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Previous measurements of the electronic conductance of DNA nucleotides or amino acids have used tunnel junctions in which the gap is mechanically adjusted, such as scanning tunneling microscopes or mechanically controllable break junctions. Fixed-junction devices have, at best, detected the passage of whole DNA molecules without yielding chemical information. Here, we report on a layered tunnel junction in which the tunnel gap is defined by a dielectric layer, deposited by atomic layer deposition. Reactive ion etching is used to drill a hole through the layers so that the tunnel junction can be exposed to molecules in solution. When the metal electrodes are functionalized with recognition molecules that capture DNA nucleotides via hydrogen bonds, the identities of the individual nucleotides are revealed by characteristic features of the fluctuating tunnel current associated with single-molecule binding events. |
| Databáze: | OpenAIRE |
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