Influence of thyroxine on serum soluble interleukin-2 receptor alpha levels in thyroid disorders
| Autor: | Jedrzejowska-Szypułka H, Sitkiewicz A, Agnieszka Berdowska, Renata Polaniak, Jerzy Jochem, Korzonek-Szlacheta I, Ewa Birkner, Krystyna Zwirska-Korczala |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Graves' disease Thyroiditis Antithyroid Agents Hypothyroidism immune system diseases Internal medicine medicine Humans Pharmacology (medical) Subclinical infection Pharmacology Autoimmune disease Methimazole business.industry Antithyroid agent Thyroid Interleukin-2 Receptor alpha Subunit Thyroiditis Autoimmune Thyroidectomy Receptors Interleukin Middle Aged medicine.disease Thyroid Diseases Graves Disease Thyroxine Endocrinology medicine.anatomical_structure Case-Control Studies Female Thyroid function business |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 29:151-156 |
| ISSN: | 1365-2710 0269-4727 |
| Popis: | BACKGROUND Activation of cell-mediated immunity by soluble interleukin-2 receptor alpha (sIL-2Ralpha) release is well documented. The aim of this study was to measure serum concentrations of sIL-2Ralpha in patients with autoimmune and non-autoimmune thyroid disorders in different stages of thyroid function, before and after administration of l-thyroxine (l-T4) and its discontinuation as well as before and during methimazole administration. MATERIALS AND METHODS The study included 80 females: 16 with Graves' disease, 15 with Hashimoto's thyroiditis and subclinical hypothyroidism, 14 with Hashimoto's thyroiditis with fibrosis and clinical hypothyroidism, 20 after subtotal thyroidectomy following nodular non-toxic goitre and 15 healthy controls. Patients were examined at two different time points. Serum concentrations of sIL-2Ralpha were measured with the use of enzyme immunoassay technique. RESULTS Souble IL-2Ralpha serum concentration increased in patients with untreated Graves' disease and decreased after methimazole treatment. In Hashimoto's thyroiditis, the sIL-2Ralpha level was within the normal range, in Hashimoto's thyroiditis with clinical hypothyreosis it was low and after l-T4 administration it increased in both patient groups. After thyroidectomy, patients treated with l-T4, had increased levels of sIL-2Ralpha which decreased after discontinuation of therapy. There were a significant positive correlation between sIL-2Ralpha and free thyroxine in patients with (i). Graves' disease both before and after methimazole administration, (ii). Hashimoto's thyroiditis (with subclinical hypothyroidism) both before and after l-T4 therapy, (iii). Hashimoto's thyroiditis with fibrosis and (iv). overt hypothyroidism before l-T4 administration and in individuals during long-term l-T4 treatment (after subtotal thyroidectomy). CONCLUSION Serum sIL-2Ralpha concentration in autoimmune thyroid diseases depends on thyroid function. In both autoimmune and non-autoimmune thyroid diseases, thyroxine stimulates the release of sIL-2Ralpha. |
| Databáze: | OpenAIRE |
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