Voluntary versus ABC breath-hold in the context of VMAT for breast and locoregional lymph node radiotherapy including the internal mammary chain
| Autor: | Emma J. Harris, Ellen M. Donovan, Alex Dunlop, Alex Grimwood, Anna M. Kirby, A. Ranger, Helen McNair, Jo Havilland, Emily Durie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cone beam computed tomography
Voluntary breath hold medicine.medical_treatment Population R895-920 Context (language use) VMAT Breast radiotherapy Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Breast cancer Medicine Radiology Nuclear Medicine and imaging education Lymph node Internal mammary chain RC254-282 Reproducibility education.field_of_study business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Bolus (digestion) Heart sparing business Nuclear medicine |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 27, Iss, Pp 164-168 (2021) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • VMAT in combination with voluntary deep inspiratory breath hold is a feasible alternative to machine operated techniques. • Voluntary deep inspiration breath hold (vDIBH) can be used in combination with wax bolus. • A novel low cost couch mounted laser offers a reliable method for monitoring vDIBH. • Intrafraction and interfraction reproducibility is equivalent between vDIBH and ABC™ breath hold in combination with VMAT with or without wax bolus. Background Deep-inspiration breath-hold (DIBH) reduces radiation dose to the heart in patients undergoing locoregional breast radiotherapy. In the context of tangential irradiation of the breast/ chest wall, a voluntary breath hold (vDIBH) technique has been shown to be as reproducible as a machine-assisted breath hold technique using the active breathing co-ordinator (ABC™, Elekta, Crawley, UK, ABC_DIBH). This study compares set-up reproducibility for vDIBH versus ABC_DIBH in patients undergoing volumetric-modulated arc radiotherapy (VMAT) for breast cancer, both with and without wax bolus. Method Patients with breast cancer requiring pan regional lymph node VMAT +/− wax bolus in breath-hold were CT scanned in vDIBH and ABC_DIBH. Patients were randomised to receive one technique for fractions 1–7 and the other for fractions 8–15. Daily cone beam computed tomography (CBCT) was performed and registered to planning-CT using bony anatomy. Within-patient comparisons of mean daily chest wall position were made using a paired t-test. Population, systematic (∑) and random errors (α) were estimated. Intrafraction reproducibility was assessed by comparing chest wall position and diaphragm movement between consecutive breath holds on CBCT. Results 16 patients were recruited. All completed treatment with both techniques (9 patients with wax bolus, 7 patients without). CBCT derived ∑ were 2.1–6.4 mm (ABC_DIBH) and 2.1–4.9 mm (vDIBH), α were 1.7–2.6 mm (ABC_DIBH) and 2.2–2.7 mm (vDIBH) and mean daily chest wall displacements (MD) were 0.0–1.5 mm (ABC_DIBH) and -0.1–1.6 vDIBH (all p non-significant). Chest wall and diaphragm position was equivalent between consecutive breath holds in ABC and vDIBH (median difference 1.0 mm and 0.8 mm respectively, non p significant) demonstrating equivalent intrafraction reproducibility. Conclusion This study demonstrates that a simple voluntary breath hold technique is feasible in combination with VMAT (+/− bolus) and is as reproducible as ABC_DIBH with VMAT for the irradiation of the breast and axillary and IMC lymph nodes in breast cancer patients. |
| Databáze: | OpenAIRE |
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