Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross
Autor: | Timothy A. Bell, Yuying Xie, David W. Threadgill, Tavia Clark, Fernando Pardo-Manuel de Villena, Jill Steigerwalt, Chevonne D. Eversley |
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Rok vydání: | 2010 |
Předmět: |
Male
lcsh:QH426-470 Genotype Mus spretus Mice Inbred A Inheritance Patterns Single-nucleotide polymorphism 03 medical and health sciences symbols.namesake Mice 0302 clinical medicine Inbred strain Genetics Animals Genetics(clinical) Allele Genetics (clinical) Alleles 030304 developmental biology 0303 health sciences biology Models Genetic Chromosome Mapping biology.organism_classification lcsh:Genetics Meiotic drive Evolutionary biology Mendelian inheritance symbols Hybridization Genetic Female 030217 neurology & neurosurgery Microsatellite Repeats Research Article |
Zdroj: | BMC Genetics BMC Genetics, Vol 11, Iss 1, p 98 (2010) |
ISSN: | 1471-2156 |
Popis: | Background Transmission ratio distortion (TRD), defined as statistically significant deviation from expected 1:1 Mendelian ratios of allele inheritance, results in a reduction of the expected progeny of a given genotype. Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss. Results Three independent events of statistically significant deviation from the expected 50:50 Mendelian inheritance ratios were observed in an interspecific backcross between the Mus musculus A/J and the Mus spretus SPRET/EiJ inbred strains. At weaning M. musculus alleles are preferentially inherited on Chromosome (Chr) 7, while M. spretus alleles are preferentially inherited on Chrs 10 and 11. Furthermore, alleles on Chr 3 modify the TRD on Chr 11. All TRD loci detected at weaning were present in Mendelian ratios at mid-gestation and at birth. Conclusions Given that Mendelian ratios of inheritance are observed for Chr 7, 10 and 11 during development and at birth, the underlying causes for the interspecific TRD events are the differential post-natal survival of pups with specific genotypes. These results are consistent with the TRD mechanism being deviation from Mendelian inheritance rather than meiotic drive or segregation distortion. |
Databáze: | OpenAIRE |
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