Patient outcome according to the 2017 international consensus on the definition of borderline resectable pancreatic ductal adenocarcinoma
| Autor: | Jean-Robert Delpero, Jacques Ewald, Jonathan Garnier, Marine Gilabert, Marc Giovannini, U. Marchese, S. Launay, Olivier Turrini, Flora Poizat, J. Medrano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Consensus Pancreatic ductal adenocarcinoma FOLFIRINOX Endocrinology Diabetes and Metabolism medicine.medical_treatment Leucovorin Irinotecan 03 medical and health sciences Pancreatectomy 0302 clinical medicine Borderline resectable Regional lymph node metastasis Antineoplastic Combined Chemotherapy Protocols medicine Back pain Humans Aged Neoplasm Staging Aged 80 and over Hepatology Performance status business.industry Gastroenterology Induction chemotherapy Middle Aged Reference Standards Survival Analysis Oxaliplatin Pancreatic Neoplasms Treatment Outcome Lymphatic Metastasis 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Fluorouracil Radiology medicine.symptom business Carcinoma Pancreatic Ductal |
| Zdroj: | Pancreatology. 20:223-228 |
| ISSN: | 1424-3903 |
| Popis: | We evaluated the usefulness of the 2017 definition of borderline pancreatic ductal adenocarcinoma (BR-PDAC) in fit patients (performance status 0-1) based on anatomical (A) and biological dimensions (B).From 2011 to 2018, 139 resected patients with BR-PDAC according to the 2017 definition were included: 18 patients underwent upfront pancreatectomy (CA 19-9 500 U/mL and/or regional lymph node metastasis; BR-B group), and 121 received FOLFIRINOX (FX) induction chemotherapy and were divided into BR-A (CA 19-9 500 U/mL, no regional lymph node metastasis; n = 68) and BR-AB (CA 19-9 500 U/mL and/or regional lymph node metastasis; n = 53) groups.The 3 groups were comparable according to patient characteristics (except for back pain (P .01) and CA 19-9 (P .01)), intraoperative data, and postoperative courses. BR-AB patients required more venous resections (P .01). The 3 groups were comparable on pathologic findings, except that BR-B patients had more lymph node invasions (P = .02). Median overall survival (OS) of the 121 patients was 45 months. In multivariate analysis, venous resection (P = .039) and R1 resection (P = .012) were poorly linked with OS, whereas BR-A classification (P .01) independently favored OS. Median survival times of BR-A, BR-AB, and BR-B groups were undetermined, 27 months, and 20 months (P.001), respectively.The 2017 definition was relevant for sub-classifying patients with BR-PDAC. The anatomical dimension (BR-A) was a favorable prognostic factor, whereas the biological dimension (BR-AB and BR-B) poorly impacted survival. |
| Databáze: | OpenAIRE |
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