Sol–gel based synthesis and biological properties of zinc integrated nano bioglass ceramics for bone tissue regeneration

Autor: Murugesan Ramachandran, Pragyan Paramita, Srinivasan Narashiman, Tze Wen Chung, Dinesh Kumar Sukumar, Selvamurugan Nagarajan, Moorthi Ambigapathi
Rok vydání: 2021
Předmět:
Ceramics
Bone Regeneration
Metal Nanoparticles
Nanoparticle
Biocompatible Materials
02 engineering and technology
Regenerative Medicine
Bone tissue
01 natural sciences
law.invention
Mice
Osteogenesis
law
Materials Testing
Nanotechnology
Mice
Inbred C3H
Tissue Scaffolds
Bone Cements
Biomaterial
Cell Differentiation
021001 nanoscience & nanotechnology
Anti-Bacterial Agents
Zinc
medicine.anatomical_structure
Bioactive glass
Biocompatibility Studies
0210 nano-technology
Materials science
Biomedical Engineering
Biophysics
chemistry.chemical_element
Bioengineering
Bone healing
In Vitro Techniques
010402 general chemistry
Bone and Bones
Phase Transition
Biomaterials
medicine
Animals
Humans
Regeneration
Cell Proliferation
Sol-gel
Osteoblasts
Tissue Engineering
Regeneration (biology)
Nanostructures
0104 chemical sciences
Durapatite
chemistry
Biofilms
Adsorption
Biomedical engineering
Zdroj: Journal of Materials Science. Materials in Medicine
ISSN: 1573-4838
0957-4530
DOI: 10.1007/s10856-020-06478-3
Popis: Bone is a flexible and electro active tissue that is vulnerable to various traumatic injuries. The self-healing of damaged bone tissue towards reconstruction is limited due to the lack of proper niche compliances. Nevertheless, the classical grafting techniques like autograft/allograft for bone repair pose challenges like bacterial infections and donor-site morbidity with unsatisfactory outcomes. The use of appropriate biomaterial with osteogenic potential can meet these challenges. In this regard, bioactive glass ceramics is widely used as a bone filler or graft material because of its bonding affinity to bone leading towards bone reconstruction applications without the challenge of post implant infections. Hence, the current study is aimed at addressing this potentiality of zinc (Zn) for doped the bioglass at nano-scale advantages for bone tissue repair. Since, Zn has been demonstrated to have not only antibacterial property but also the stimulatory effect on osteoblasts differentiation, mineralization by enhancing the osteogenic genes expression. In view of these, the present study is focused on sol–gel synthesis and pysico-chemical characterization of Zinc-doped bioglass nanoparticles (Zn-nBGC) and also analyzing its biological implications. The surface morphological and physiochemical characterizations using SEM, EDX, FT-IR and XRD analysis has shown the increased surface area of Zn-nBGC particles providing a great platform for biomolecular interaction, cytocompatibility, cell proliferation and osteogenic differentiation. The obtaining hydroxy apatite groups have initiated in vitro mineralization towards osteogenic lineage formation. Zn has not only involved in enhancing cellular actions but also strengthen the ceramic nanoparticles towards antibacterial application. Hence the finding suggests a biomaterial synthesis of better biomaterial for bone tissue engineering application by preventing post-operative bacterial infection.
Databáze: OpenAIRE
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