Triterpenoid saponins from the roots ofClematis chinensisOsbeck

6)-O-beta-D-glucopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 4)-O-beta-D-ribopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl)oxy]olean-12-en-21alpha-hydroxy-28-oic acid-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (1) by spectral analysis and chemical methods. The effects of two major saponins (clematichinenosides AR and AR(2)) on the secretion of TNF-alpha in murine peritoneal macrophages induced by lipopolysaccharides were further investigated. The result indicated that a majority of triterpenoid saponins of this herb may be useful in the exploration of lead compounds for the treatment of some autoimmune diseases. -->

ISSN:	1477-2213 1028-6020
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5a27facc1e33d8a31110331c6cc90d https://doi.org/10.1080/10286020902867268
Přírůstkové číslo:	edsair.doi.dedup.....1e5a27facc1e33d8a31110331c6cc90d
Autor:	Yuxin Wang, Zhu-Qing Wan, Xiao-Li Ma, Yunman Li, Qiu-Ling Tang, Fengwen Li, Lifang Liu
Rok vydání:	2009
Předmět:	Male Stereochemistry Chemical structure Saponin Pharmaceutical Science Ranunculaceae Pharmacognosy Plant Roots Analytical Chemistry Mice Triterpene Drug Discovery Animals Oleanolic Acid Clematis Triterpenoid saponin Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure biology Traditional medicine Tumor Necrosis Factor-alpha Organic Chemistry Glycoside General Medicine Saponins biology.organism_classification Triterpenes Terpenoid carbohydrates (lipids) Complementary and alternative medicine chemistry Macrophages Peritoneal Molecular Medicine Drugs Chinese Herbal
Zdroj:	Journal of Asian Natural Products Research. 11:389-396
ISSN:	1477-2213 1028-6020
Popis:	A new triterpenoid saponin named clematichinenoside AR(2), along with the six known compounds, was isolated and characterized from Clematis chinensis Osbeck (Ranunculaceae), a commonly used traditional Chinese medicine with anti-inflammatory and anti-rheumatoid activities. The structure of the new saponin was elucidated as 3-O-beta-[(O-alpha-L-rhamnopyranosyl-(1 --> 6)-O-beta-D-glucopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 4)-O-beta-D-ribopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl)oxy]olean-12-en-21alpha-hydroxy-28-oic acid-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (1) by spectral analysis and chemical methods. The effects of two major saponins (clematichinenosides AR and AR(2)) on the secretion of TNF-alpha in murine peritoneal macrophages induced by lipopolysaccharides were further investigated. The result indicated that a majority of triterpenoid saponins of this herb may be useful in the exploration of lead compounds for the treatment of some autoimmune diseases.
Databáze:	OpenAIRE
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