Prostaglandins in enhanced pressor response in renal prehypertensive rabbits
| Autor: | Kunio Sato, Shuichi Ichikawa, Tetsuya Nakamura, Atsuko Yagi, Shunichi Yagi, Kazuhiko Murata, Masami Kogure, Haruyasu Fujita, Hisao Kumakura, Masao Fujie |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Indomethacin Hemodynamics Prostaglandin Blood Pressure Pressoreceptors Renal artery stenosis Dinoprostone General Biochemistry Genetics and Molecular Biology Norepinephrine (medication) Norepinephrine chemistry.chemical_compound Heart Rate Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Kidney Lagomorpha biology business.industry Angiotensin II Prostaglandins E General Medicine medicine.disease biology.organism_classification Epoprostenol Hypertension Renovascular medicine.anatomical_structure Endocrinology chemistry Prostaglandins cardiovascular system Rabbits business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Life Sciences. 40:1277-1286 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(87)90584-4 |
| Popis: | The role of prostaglandins (PGs) in the pressor response to norepinephrine (NE) was examined in one-kidney, one clip rabbits with renal artery stenosis for 3-day's duration (3-day clipped rabbits) and in sham operated rabbits with one-kidney without renal artery stenosis. An exaggerated pressor response to NE, 800 ng/kg/min, was observed in the 3-day clipped rabbits, and it was abolished by angiotensin II antagonist, [Sar1, Ile8] angiotensin II (AIIA). Treatment with indomethacin, 10 mg/kg, induced hyperresponsiveness to NE in the sham operated rabbits and also produced a further increase in the response in the 3-day clipped rabbits: the enhanced responses with similar levels were not attenuated by AIIA in both groups. A subdepressor dose of PGE2, 800 ng/kg/min, abolished the hyperresponsiveness in the 3-day clipped rabbits, while subdepressor or depressor dose of PGI2, 10 or 20 ng/kg/min did not, but the concurrent infusion of AIIA with PGI2 attenuated it. These results indicate that PGs, in particular PGE2 might be involved in the enhanced pressor response to NE in the 3-day clipped rabbits in addition to the altered renin-angiotensin system. |
| Databáze: | OpenAIRE |
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