The Effect of Ultra–low-dose Intrathecal Naloxone on Pain Intensity After Lumbar Laminectomy With Spinal Fusion: A Randomized Controlled Trial
| Autor: | Sajad Shafiei, Alieh Zamani Kiasari, Abolfazl Firouzian, Saeid Ehteshami, Kaveh Haddadi, Abbas Alipour, Afshin Gholipour Baradari, Shahram Ala, Fatemeh Younesi Rostami, Hadi Darvishi-Khezri, Misagh Shafizad |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Visual analogue scale Nausea Narcotic Antagonists medicine.medical_treatment 03 medical and health sciences Postoperative Complications 0302 clinical medicine Double-Blind Method 030202 anesthesiology Naloxone medicine Humans Adverse effect Injections Spinal Aged Pain Measurement Pain Postoperative Lumbar Vertebrae business.industry Pruritus Laminectomy Analgesia Patient-Controlled Middle Aged Spinal Fusion Anesthesiology and Pain Medicine Anesthesia Spinal fusion Postoperative Nausea and Vomiting Morphine Vomiting Female Surgery Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neurosurgical Anesthesiology. 32:70-76 |
| ISSN: | 0898-4921 |
| DOI: | 10.1097/ana.0000000000000537 |
| Popis: | BACKGROUND Despite advances in pain management, several patients continue to experience severe acute pain after lumbar spine surgery. The aim of this study was to assess the safety and effectiveness of single ultra-low-dose intrathecal (IT) naloxone in combination with IT morphine for reducing pain intensity, pruritus, nausea, and vomiting in patients undergoing lumbar laminectomy with spinal fusion. MATERIALS AND METHODS In this double-blind trial, patients scheduled for lumbar laminectomy with spinal fusion were randomly assigned to receive single ultra-low-dose IT naloxone (20 μg) and IT morphine (0.2 mg) (group M+N) or IT morphine (0.2 mg) alone (group M). The severity of postoperative pain, pruritus and nausea, and frequency of vomiting were assessed at recovery from anesthesia and, subsequently, at 1, 3, 6, 12, and 24 hours postoperatively using an 11-point (0-10) visual analogue scale. RESULTS A total of 77 patients completed the study, and there were significant differences in postoperative pain, pruritus, and nausea visual analogue scale between the groups (P |
| Databáze: | OpenAIRE |
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