The Effect of Body Mass Index on Initial Breast Cancer Stage Among Korean Women
| Autor: | Yongwoong Lee, Kyung-Hwak Yoon, Byeongju Kang, Haemin Lee, Eunyoung Kang, Hee Chul Shin, Eun Kyu Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty Breast Neoplasms Comorbidity Palpation Body Mass Index 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Humans Medicine In patient Obesity Stage (cooking) Neoplasm Staging medicine.diagnostic_test business.industry Cancer stage Age Factors nutritional and metabolic diseases Middle Aged Prognosis medicine.disease 030104 developmental biology Oncology Normal weight 030220 oncology & carcinogenesis Female business Body mass index |
| Zdroj: | Clinical Breast Cancer. 21:e631-e637 |
| ISSN: | 1526-8209 |
| DOI: | 10.1016/j.clbc.2021.04.007 |
| Popis: | The relationship between obesity and breast cancer stage is not well-known in the Korean population. This study aimed to identify the effect of body mass index (BMI) on initial breast cancer stage.Among patients who underwent surgery for breast cancer (stages 0-III) from June 2003 to December 2018, we analyzed 4510 patients for whom there were BMI data.The average BMI of our patients was 23.5 (14.2-44.9). In total, 4.6% and 24.2% of the patients had a BMI of ≥30 and 25-29.9, respectively. In the patients with obesity, the proportion of T2 to T4 was 41.4%, which was higher than that in patients with a BMI of 25 to 29 (28.4%; P = .001) or a BMI of25 (23.3%; P.001). There was no difference in positive rates of estrogen receptor and progesterone receptor with BMI, but obese patients were less likely to be human epidermal growth factor receptor 2 positive. Patients with higher stages were more likely to have a higher BMI. The effect of BMI on stage was stronger in patients50 years (odds ratio, 2.439; 95% CI, 1.783-3.335). Although there was no statistical significance, tumors2 cm were less likely to be palpable in obese patients than in patients of normal weight (nonpalpable in 33.8% and 27.0%, respectively).Our study suggests that obesity is associated with a more advanced breast cancer stage, which represents a poor prognosis, and large tumors tend to be less palpable in women with obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect