Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

Autor:	Hamid R. Nasiri, Steffen Lang, Gunther Wittstock, Ulrich Groth, Robin Panisch, Nadine Jacobs
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Natural product Calculated data Synthetic derivatives Chemistry General Chemical Engineering ddc:540 General Chemistry Marcanine A Electrochemistry Cytotoxicity Combinatorial chemistry Derivative (chemistry)
Zdroj:	RSC Advances. 5:58561-58565
ISSN:	2046-2069
DOI:	10.1039/c5ra11078e
Popis:	The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies. To enable a structure–toxicity-relationship of the natural product, eleven novel synthetic derivatives with different electrochemical properties were synthesized and tested. Derivative 5 revealed a GI50 in the low μM range, being more active than the actual natural product. A clear correlation was found between the experimental and the calculated data. published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e53017726e7d6be996e73681017b42e https://doi.org/10.1039/c5ra11078e Zobrazit plný text záznamu