Human glomerular mesangial cells inactivate leukotriene B4 by reduction into dihydro-leukotriene B4 metabolites
| Autor: | K. Wessel, V. Kaever, Juergen Floege, B. Damerau, G. Zimmer, N Topley, J. Bruuns, Heinfried H. Radeke, Klaus Resch, J. Fauler, J. Wunder |
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| Rok vydání: | 1990 |
| Předmět: |
Leukotriene
Mesangial cell Neutrophils Leukotriene B4 Glomerular Mesangial Cell Metabolite Chemotaxis General Medicine General Biochemistry Genetics and Molecular Biology Glomerular Mesangium Chemotaxis Leukocyte chemistry.chemical_compound chemistry Biochemistry Cell culture Humans General Pharmacology Toxicology and Pharmaceutics Oxidation-Reduction Cells Cultured Chromatography High Pressure Liquid Leukocyte chemotaxis |
| Zdroj: | Life Sciences. 46:1465-1470 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(90)90463-2 |
| Popis: | Due to its potent chemotactic properties leukotriene B4 is an important mediator of inflammatory reactions. Cultured human kidney mesangial cells converted exogenously added leukotriene B4 efficiently into three different more lipophilic metabolites, two of them probably representing dihydro-leukotriene B4 isomers. This represents an alternative metabolic pathway, in contrast to leukotriene B4 omega-oxidation found in human polymorphonuclear leukocytes. Both dihydro-leukotriene B4 isomers had nearly completely lost their ability to induce leukocyte chemotaxis as compared to leukotriene B4. |
| Databáze: | OpenAIRE |
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