In vitro degradability and bioactivity of oxidized bacterial cellulose-hydroxyapatite composites
| Autor: | Paulo Hiago Silva Chaves, Sádwa Fernandes Ribeiro, Morsyleide de Freitas Rosa, Lídia de Araújo Pinto Vieira, Erika Patricia Chagas Gomes Luz, Rodrigo Silveira Vieira, Antonia Infantes-Molina, Maria de Fátima Borges, Enrique Rodríguez-Castellón, Celli Rodrigues Muniz, Fábia Karine Andrade |
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| Rok vydání: | 2020 |
| Předmět: |
Bone Regeneration
Polymers and Plastics 02 engineering and technology 010402 general chemistry 01 natural sciences Butyric acid Acetic acid chemistry.chemical_compound Materials Chemistry Composite material Cellulose Bone regeneration Acetic Acid Tissue Engineering Chemistry Organic Chemistry Chemical modification 021001 nanoscience & nanotechnology Body Fluids 0104 chemical sciences Durapatite Glucose Membrane Bacterial cellulose Acetobacteraceae Butyric Acid Degradation (geology) 0210 nano-technology Hybrid material Oxidation-Reduction |
| Zdroj: | Carbohydrate Polymers. 237:116174 |
| ISSN: | 0144-8617 |
| Popis: | Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications. |
| Databáze: | OpenAIRE |
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