| Popis: |
Study included 313 normoalbuminuric T1DM with estimated glomerular filtration rate (eGFR) > 60 mlmin-11.73m-2. Serum creatinine was significantly associated with BMI, HbA1c, HDL- cholesterol, SBP and HR, with HR showing the strongest correlation (r = −0.17, p = 0.002). eGFR was significantly associated with duration of diabetes, HbA1c, LDL cholesterol, and HDL cholesterol, with duration of diabetes showing the strongest correlation (r = −0.29, p < 0.001). UAE significantly correlated with duration of diabetes, HDL cholesterol, triglycerides, HR and DBP, with HR and DBP showing the strongest correlation (r = 0.21– 0.23, p < 0.001). Subjects in the 4th quartile of UAE had significantly higher HR rate compared to subjects in 1st, 2nd, and 3rd quartiles (70 ± 11 vs 74 ± 12 vs 74 ± 12 vs 79 ± 13 beats/min, p = 0.001). Subjects in the 4th quartile of serum creatinine had significantly lower HR compared to subjects in 1st, 2nd, and 3rd quartiles (77 ± 13 vs 75 ± 13 vs 73 ± 11 vs 71 ± 13 betas/min, p = 0.03). Results of our study suggest that interplay between HR and renal function parameters are present even in T1DM with normal renal function and that higher HR may be predictor for higher UAE in those subjects. |
