Ketamine ameliorates depressive-like behaviors and immune alterations in adult rats following maternal deprivation
| Autor: | João Quevedo, Francieli Vuolo, Helena M. Abelaira, Renata C. Gonçalves, Débora B. Tomaz, Felipe Dal-Pizzol, André F. Carvalho, Maria Augusta B Dos Santos, Jaine R. da Luz, Anelise S. Carlessi, Marcos Paulo Nacif, Gislaine Z. Réus |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Glutamatergic Immune system Internal medicine medicine Animals Ketamine Rats Wistar Receptor Maternal deprivation Depression Interleukin-6 Tumor Necrosis Factor-alpha Maternal Deprivation General Neuroscience Antagonist Glutamate receptor Antidepressive Agents Endocrinology Cytokines NMDA receptor Female Psychology Interleukin-1 medicine.drug |
| Zdroj: | Neuroscience Letters. 584:83-87 |
| ISSN: | 0304-3940 |
| Popis: | A growing body of evidence points toward an association between the glutamatergic system, as well as immune system dysregulation and major depression. So, the present study was aimed at evaluating the behavioral and molecular effects of the ketamine, an antagonist of the N-methyl-D-aspartate (NMDA) receptor of glutamate in maternally deprived adult rats. In deprived rats treated with saline, we observed an increase in the immobility time; however, ketamine treatment reversed this effect, decreasing immobility time. In addition, maternal deprivation induced an increase in cytokines: TNF-α and IL-1 in serum, and in IL-6 in serum and cerebrospinal fluid (CSF). Interestingly, ketamine treatment reduced the levels of all the cytokines in deprived rats. In conclusion, these findings further support a relationship between immune activation and depression. Considering the action of ketamine, this study suggested that antagonists of the NMDA receptor, such as ketamine, could exert their effects by modulation of the immune system. |
| Databáze: | OpenAIRE |
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