Heterogeneous Expression of Embryonal Development Master Regulator SOX9 in Patients with Pancreatic Cancer
| Autor: | V. I. Egorov, E. P. Kopantzev, L. G. Kondratyeva, M. V. Zinovyeva, E. D. Sverdlov, Igor P. Chernov |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system animal structures Biophysics Embryonic Development SOX9 Biology Biochemistry Andrology 03 medical and health sciences Fetus Text mining stomatognathic system Pancreatic cancer Gene expression medicine Humans Gene Regulation of gene expression 030102 biochemistry & molecular biology business.industry SOX9 Transcription Factor General Chemistry General Medicine musculoskeletal system medicine.disease Gene Expression Regulation Neoplastic Pancreatic Neoplasms 030104 developmental biology Expression (architecture) embryonic structures business |
| Zdroj: | Doklady Biochemistry and Biophysics. 481:208-211 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | The expression levels of the SOX9 gene in fetal, postnatal, and neoplastic pancreatic tissues were compared. In the fetal pancreatic samples, the mean relative level of the SOX9 gene expression was 8 times greater than the normal level. The tumor samples were divided into three groups depending on the SOX9 expression level. The first group showed a 6.5-fold increased expression level of SOX9 with respect to the normal one. The second and normal groups had approximately equal levels expression. The third group showed a 25-fold decreased expression level of SOX9. The discrepancy in the SOX9 expression, associated with the predominance of different functions of this master gene, depends on the poorly predictable individual factors and indicates that SOX9 should be excluded from the potential diagnostic biomarkers of pancreatic cancer. |
| Databáze: | OpenAIRE |
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