| Autor: |
Nada Mehio, Heather L. Frericks Schmidt, Geoffrey P.F. Wood, Bruno C. Hancock, Ravi M. Shanker, Jeremy A. Bartlett, Sheri L. Shamblin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 623 |
| ISSN: |
1873-3476 |
| Popis: |
Multiparticulate formulations allow for the design of specialized pharmaceutical dosage forms that cater to the needs of a wide range of patient demographics, such as pediatric and geriatric populations, by affording control over the release rate and facilitating the formulation of fixed-dose combination drugs. Melt spray-congealing (MSC) is a method for preparing multiparticulate dosage forms from a suspension or solid solution of active pharamaceutical ingredients (API) and a molten carrier matrix. Stearyl alcohol and poloxamer 407 mixtures are widely used as carrier matrices in MSC microsphere formulations. In this report, the phase equilibria of stearyl alcohol-poloxamer 407 mixtures were investigated by generating binary phase diagrams of composition, i.e. weight/weight percent of poloxamer 407 in stearyl alcohol, and temperature in the molten form and the solid state. The phase equilibria of the molten state were characterized by |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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