Protometric thermometric titrations of sparingly soluble compounds in water in the presence of n-octanol
| Autor: | J.-L. Burgot, G. Burgot |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Octanol
chemistry.chemical_classification Chemistry fungi Clinical Biochemistry Inorganic chemistry Titrimetry Water Pharmaceutical Science Hydrochloric acid 1-Octanol Calorimetry Analytical Chemistry Dissociation constant chemistry.chemical_compound Solubility Sodium hydroxide Phenothiazine Drug Discovery Titration Counterion Spectroscopy Thermometric titration |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 30:625-634 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(02)00355-2 |
| Popis: | Thermometric titrimetry permits titration of acido–basic compounds in water in the presence of n-octanol. n-Octanol permits the solubilization of protolytes and moreover may also displace the equilibria of the titration reactions. Hydrochlorides of highly insoluble derivatives such as phenothiazine derivatives can be titrated with satisfactory accuracy and precision by sodium hydroxide despite their high pKa values. Likewise barbiturate salts can be titrated by hydrochloric acid. In the case of some salts, the methodology may permit the sequential titration of the ion and counter ion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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