Effectiveness of rotavirus vaccines for prevention of rotavirus gastroenteritis-associated hospitalizations in Israel: A case-control study
| Autor: | Adi Kremer, Uri Rubinstein, Dani Cohen, Moshe Ephros, Lester M. Shulman, Eias Kasem, Gabby Chodick, Sophy Goren, Ilana Zilberstein, Jacob Shachter, Khitam Muhsen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent viruses Immunology Rotavirus gastroenteritis Rotavirus vaccination medicine.disease_cause Rotavirus Infections fluids and secretions Rotavirus medicine Humans Israel General Pharmacology Toxicology and Pharmaceutics Child business.industry Rotavirus Vaccines Case-control study virus diseases Rotavirus vaccine Gastroenteritis Hospitalization Diarrhea El Niño Case-Control Studies Female medicine.symptom business |
| Zdroj: | Human Vaccines. 6:450-454 |
| ISSN: | 1554-8619 1554-8600 |
| DOI: | 10.4161/hv.6.6.11759 |
| Popis: | The association between rotavirus gastroenteritis (RVGE)-associated hospitalization and rotavirus vaccine receipt was examined, and vaccine effectiveness was estimated in a case-control study conducted between 11/2007 and 12/2009 among Israeli children age eligible for rotavirus vaccination. Cases (n=111) were hospitalized children with diarrhea testing positive for rotavirus by immunochromatography. Controls (n=216) were hospitalized children with diarrhea testing negative for rotavirus. Among controls 36 (16.7%) children were vaccinated against rotavirus compared with two children (1.8%) among cases (p0.001). Rotavirus immunization was associated with lower risk of RVGE-associated hospitalization; adjusted OR 0.106 (95% CI 0.024, 0.481), yielding a vaccine effectiveness of 89.4% (95% CI 51.9%, 97.6%) in preventing hospitalization. These data demonstrate high effectiveness of rotavirus vaccines in a high income country. |
| Databáze: | OpenAIRE |
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