Double Transfer of Chirality in Organocopper-Mediated bis(Alkylating) Cycloisomerization of Enediynes
| Autor: | Malek Nechab, Dominique Mouysset, Nicolas Vanthuyne, Michèle P. Bertrand, Cyril Borie, Tanzeel Arif, Jean-Valère Naubron, Damien Campolo |
|---|---|
| Přispěvatelé: | Chimie, biologie et radicaux libres - UMR 6517 (CBRL), Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Spectropôle - Aix Marseille Université (AMU SPEC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
inorganic chemicals
010405 organic chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Chemistry Stereochemistry organic chemicals Enantioselective synthesis General Medicine General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences 3. Good health Enantiopure drug Cycloisomerization Reagent health occupations polycyclic compounds heterocyclic compounds Chirality (chemistry) ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Angewandte Chemie International Edition Angewandte Chemie International Edition, Wiley-VCH Verlag, 2014, 53 (12), pp.3227-3231. ⟨10.1002/anie.201310530⟩ Angewandte Chemie International Edition, 2014, 53 (12), pp.3227-3231. ⟨10.1002/anie.201310530⟩ |
| ISSN: | 1433-7851 1521-3773 |
| Popis: | An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo-, regio-, diastereo-, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central-to-axial-to-central) is observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text