High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification

Autor: Nicolas Vitale, Isabelle Dugail, Ez-Zoubir Amri
Přispěvatelé: Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Angiotensin receptor
Coronavirus disease 2019 (COVID-19)
BMI
body mass index
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
[SDV]Life Sciences [q-bio]
AT
angiotensin receptors
Adipose tissue
nAChRs
nicotinic acetylcholine receptors
Bioinformatics
PD-1
programmed cell death receptor 1
Biochemistry
Article
AGT
angiotensinogen
RAS
renin angiotensin system
03 medical and health sciences
SARS-CoV-2
Severe acute respiratory syndrome coronavirus-2
LDL
low-density lipoprotein
Prevalence
Humans
Medicine
Obesity
NLRP3
NOD-like receptor family pyrin domain containing 3
TMPRSS2
transmembrane protease serine 2
Risk factor
Receptor
PUFA
polyunsaturated fatty acids
ACE2
angiotensin-converting enzyme II
030102 biochemistry & molecular biology
TNFα
tumor necrosis factor-alpha
business.industry
MERS
Middle East respiratory syndrome
PAI-1
Plasminogen Activator Inhibitor-1
COVID-19
WAT
white adipose tissue
General Medicine
medicine.disease
COVID-19
corona virus disease 2019
IL
interleukin
3. Good health
BAT
brown adipose tissue
030104 developmental biology
Adipose Tissue
Cytokines
business
Patient stratification
Zdroj: Biochimie
Biochimie, Elsevier, 2020, ⟨10.1016/j.biochi.2020.07.001⟩
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2020.07.001⟩
Popis: It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
Highlights • Adipose tissue may be a reservoir for SARS-CoV-2 production. • Obesity-induced chronic inflammatory status generates inappropriate immune response. • Exaggerated-adipose tissue lipolysis in response to proinflammatory cytokines might exert additional lipotoxic effects. • Potential role of adipose-derived products in aggravating COVID-19 infection. • Adipose tissue contribution to COVID-19 severity through the perturbation of local renin angiotensin system.
Databáze: OpenAIRE
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