Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes
Autor: | Elmar Krause, Hsin-Fang Chang, Jens Rettig, Hawraa Bzeih, Keerthana Ravichandran, Varsha Pattu, Praneeth Chitirala, Marwa Sleiman, Ulrike Hahn |
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Rok vydání: | 2016 |
Předmět: |
Cytotoxicity
Immunologic 0301 basic medicine SNARE proteins Correlative light and electron microscopy Recycling endosomes Endosome Endocytic cycle Review Endosomes Biology Cytoplasmic Granules Endocytosis Membrane Fusion Exocytosis Immunological synapse 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Early endosomes Animals Humans Cytotoxic T cell Molecular Biology Total internal reflection fluorescence microscopy Pharmacology Late endosomes Granule (cell biology) Degranulation Cell Biology Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine Lysosomes Intracellular T-Lymphocytes Cytotoxic |
Zdroj: | Cellular and Molecular Life Sciences |
ISSN: | 1420-9071 1420-682X |
Popis: | Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution of two intracellular compartments, endosomes and cytotoxic granules, to the formation, function and disassembly of the immunological synapse. We highlight a recently proposed sequential process of fusion events at the IS upon target cell recognition. First, recycling endosomes fuse with the plasma membrane to deliver cargo required for the docking of cytotoxic granules. Second, cytotoxic granules arrive and fuse upon docking in a SNARE-dependent manner. Following fusion, membrane components of the cytotoxic granule are retrieved through endocytosis to ensure the fast, efficient serial killing of target cells that is characteristic of cytotoxic T lymphocytes. |
Databáze: | OpenAIRE |
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