Effects of acute acid--base alterations on glutamine metabolism and renal ammoniagenesis in the dog
| Autor: | A. Fine, George Alleyne, F. I. Bennett |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Glutamine Glutamine metabolism Biology Acid-Base Imbalance Kidney Ammonia production chemistry.chemical_compound Ammonia Dogs Internal medicine medicine Animals Urea Acidosis General Medicine Endocrinology medicine.anatomical_structure chemistry Regional Blood Flow Renal blood flow Acute Disease Female medicine.symptom |
| Zdroj: | Clinical science and molecular medicine. 54(5) |
| ISSN: | 0301-0538 |
| Popis: | 1. The effects of acute acid—base alterations on renal ammonia production and glutamine metabolism were studied in anaesthetized dogs. 2. Plasma glutamine rose with acidosis and also when both Pco2 and plasma HCO−3 were raised isohydrically. 3. Blood urea fell when acidosis was induced with hydrochloric acid. 4. The renal production of ammonia per ml of renal blood flow was increased in acidosis, but this was independent of the amount of glutamine delivered to the kidney. 5. The results indicate that acute acidosis affects production of urea and glutamine and increases the capacity of the renal cells to extract glutamine from blood. |
| Databáze: | OpenAIRE |
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