Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells
| Autor: | S. Norley, P de Vries, Rob Dubbes, M. Dings, P. J. F. Ten Haaft, M. Cranage, C van Els, A Osterhaus, Ronald E. Bontrop, Margreet Jonker, Jolande Boes, Nel Otting, Jonathan L. Heeney, Henk Niphuis, Wim Koornstra |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Simian Acquired Immunodeficiency Syndrome
medicine.disease_cause Cytotoxic t lymphocyte Major histocompatibility complex restriction Glycoprotein gp 120 Immunology and Allergy Cytotoxic T cell Provocation test Measles vaccine Antibody titer biology Viral Vaccine Vaccination Simian immunodeficiency virus Articles Virus neutralization Major histocompatibility antigen class 1 Polymerase chain reaction SIV Acquired immune deficiency syndrome Antibody Animal cell Human Immunology Molecular Sequence Data Human leukocyte antigen Mononuclear cell Major histocompatibility complex Virus Serotype MHC class I medicine Humans Animals Animal model Animal experiment Amino Acid Sequence Sequence Homology Amino Acid Histocompatibility Antigens Class I Viral Vaccines Neutralizing antibody Nonhuman Virology Macaca mulatta biology.protein Rhesus monkey Virus vaccine Controlled study |
| Zdroj: | The Journal of Experimental Medicine Journal of Experimental Medicine, 2, 180, 769-774 |
| Popis: | To evaluate the effectiveness of vaccine protection from infected cells from another individual of the same species, vaccinated rhesus macaques (Macaca mulatta) were challenged with peripheral blood mononuclear cells from another animal diagnosed with acquired immune deficiency syndrome (AIDS). Half of the simian immunodeficiency virus (SIV)-vaccinated animals challenged were protected, whereas unprotected vaccinates progressed as rapidly to AIDS. Protection was unrelated to either total antibody titers to human cells, used in the production of the vaccine, to HLA antibodies or to virus neutralizing activity. However, analysis of the serotype of each animal revealed that all animals protected against cell-associated virus challenge were those which were SIV vaccinated and which shared a particular major histocompatibility complex (MHC) class I allele (Mamu-A26) with the donor of the infected cells. Cytotoxic T lymphocytes (CTL) specific for SIV envelope protein were detected in three of four protected animals vs. one of four unprotected animals, suggesting a possible role of MHC class I-restricted CTL in protection from infected blood cells. These findings have possible implications for the design of vaccines for intracellular pathogens such as human immunodeficiency virus (HIV). |
| Databáze: | OpenAIRE |
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