A cancer-associated, genome protective programme engaging PKCε
| Autor: | Ainara Lopez Pardo, Silvia Martini, Joanna M. Redmond, Jacqueline J. T. Marshall, Peter J. Parker, Marco Vitale, Khalil Davis, Tanya N. Soliman, Joanna R. Kelly, Nicola Lockwood |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Aurora B kinase Context (language use) Protein Kinase C-epsilon Computational biology Cell cycle Biology Genome Article 03 medical and health sciences 0302 clinical medicine Neoplasms Genetics medicine Humans Non-disjunction Aurora B Molecular Biology Protein kinase C Cell Proliferation Cell growth Cancer Genomics medicine.disease PKCe Biomarker 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine |
| Zdroj: | Advances in Biological Regulation |
| ISSN: | 2212-4926 |
| DOI: | 10.1016/j.jbior.2020.100759 |
| Popis: | Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data, but has for the most part not afforded clear mechanistic insights into the control mechanisms at play. Here, we review the roles of PKCε in protecting transformed cells from non-disjunction. In this particular cell cycle context, there is a growing understanding of the pathways involved, affording biomarker and interventional insights and opportunities. |
| Databáze: | OpenAIRE |
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