Theoretical investigation of ultrasound-modulated Cerenkov luminescence imaging for higher-resolution imaging in turbid media
| Autor: | Gregory S. Mitchell, Douglas N. Stephens, Simon R. Cherry, Justin S. Klein |
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| Rok vydání: | 2018 |
| Předmět: |
Quantum Physics
Materials science Scattering business.industry Resolution (electron density) Ultrasound Bioengineering Optics Optical Physics Atomic and Molecular Physics and Optics Light scattering Imaging phantom Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Biomedical Imaging Electrical and Electronic Engineering Luminescence business Image resolution Refractive index |
| Zdroj: | Optics letters, vol 43, iss 15 |
| ISSN: | 1539-4794 |
| Popis: | Cerenkov luminescence imaging (CLI) is an optical technique for imaging radiolabeled molecules in vivo. It has demonstrated utility in both the clinical and preclinical settings and can serve as a substitute for nuclear imaging instrumentation in some cases. However, optical scattering fundamentally limits the resolution and depth of imaging that can be achieved with this modality. In this Letter, we report the numerical results that support the potential for ultrasound-modulated Cerenkov luminescence imaging (USCLI), a new imaging modality that can mitigate optical scattering. The technique uses an acoustic field to modulate the refractive index of the medium and, thus, the intensity of Cerenkov luminescence in a spatially precise manner. This mechanism of contrast has not been reported previously. For a physiologically compatible ultrasound peak pressure of 1MPa, ∼0.1% of the Cerenkov signal can be modulated. Furthermore, our simulations show that USCLI can overcome the scattering limit of resolution for CLI and provide higher-resolution imaging. For an F18 point source centered in a 1 cm3 simulated tissue phantom with a scattering coefficient of μs'=10 cm-1 |
| Databáze: | OpenAIRE |
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