A case series of alopecia areata in children: impact of personal and family history of stress and autoimmunity
| Autor: | George P. Chrousos, K Karachristou, Talia Kakourou |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Alopecia Areata Dermatology Thyroid Function Tests Severity of Illness Index Thyroiditis Autoimmune Diseases Risk Factors Internal medicine medicine Humans Family history Age of Onset Child Retrospective Studies First episode Chi-Square Distribution Greece business.industry Incidence (epidemiology) Incidence Thyroid Infant Alopecia areata medicine.disease Thyroid Diseases Thyroid disorder Infectious Diseases medicine.anatomical_structure Logistic Models Case-Control Studies Child Preschool Immunology Female Age of onset business Stress Psychological |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 21(3) |
| ISSN: | 0926-9959 |
| Popis: | Background The epidemiology of alopecia areata (AA) is well documented in adults but has not been studied adequately in children. Objective To evaluate the clinical and epidemiological profile of AA in children and assess the significance of thyroid screening. Methods One hundred and fifty-seven children (83 boys, 74 girls, aged 1–16 years) who visited our clinic with a first episode of AA from 1996 to 2000 were retrospectively studied. One hundred children served as clinical controls. Results The age of peak incidence of AA was 0–5 years. The youngest child was 1 year old. In the majority of the cases (131/157, 83.4%) the disease was mild or moderate (less than 50% hair loss). In 15 patients (9.5%), AA was preceded by a stressful event. Five patients had a personal history of autoimmune disease (3.2 vs. 5% of the controls, (P = not significant [NS]) while 18 patients had a personal history of atopy (11.4 vs. 18% of the controls, P = NS). Twenty-one patients had a family history of autoimmune disease other than thyroiditis (13.4 vs. 5% of the controls, P = 0.04), while 23 patients had a family history of thyroid disorder (14.6 vs. 3% of the controls, P = 0.006). In eight patients (5%) subclinical hypothyroidism of autoimmune aetiology (Hashimoto's thyroiditis) was revealed at the time of investigation. Six out of the eight patients with Hashimoto's thyroiditis had a family history of thyroid disorder, which was statistically significant when compared to AA patients without thyroiditis (P |
| Databáze: | OpenAIRE |
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