Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
| Autor: | Nidia León-Sicairos, Ruth Reyes-Cortes, Jesús Madueña-Molina, Claudia León-Sicairos, Alma M. Guadron-Llanos, Adrian Canizalez-Roman |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cytoplasm
Phagocytosis Microorganism Iron Microbial metabolism lcsh:Medicine Review Article Biology General Biochemistry Genetics and Molecular Biology Microbiology Humans Pathogen General Immunology and Microbiology Bacteria Intracellular parasite Macrophages lcsh:R General Medicine biology.organism_classification Cell biology Cellular Microenvironment Host-Pathogen Interactions Lysosomes Intracellular |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2015 (2015) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed. |
| Databáze: | OpenAIRE |
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