The Controlling Nutritional Status Score is Significantly Associated with Complete Ulcer Healing in Patients with Critical Limb Ischemia
| Autor: | Keiji Yoshiya, Koichi Morisaki, Kentaro Inoue, Ken Nakayama, Tadashi Furuyama, Sho Yamashita, Shinichiro Yoshino, Shun Kurose, Masaki Mori, Takuya Matsumoto |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Time Factors medicine.medical_treatment 030204 cardiovascular system & hematology Single Center 030218 nuclear medicine & medical imaging 0302 clinical medicine Ischemia Risk Factors Clinical endpoint Medicine Lymphocytes Aged 80 and over Leg Ulcer General Medicine Middle Aged Limb Salvage Progression-Free Survival Cholesterol Predictive value of tests Female medicine.symptom Cardiology and Cardiovascular Medicine Vascular Surgical Procedures Cohort study medicine.medical_specialty Critical Illness Nutritional Status Serum Albumin Human Revascularization Risk Assessment Amputation Surgical 03 medical and health sciences Peripheral Arterial Disease Predictive Value of Tests Internal medicine Humans Lymphocyte Count Aged Retrospective Studies Wound Healing business.industry Retrospective cohort study Critical limb ischemia body regions Nutrition Assessment Amputation Surgery business Biomarkers |
| Zdroj: | Annals of vascular surgery. 66 |
| ISSN: | 1615-5947 |
| Popis: | Background It has been reported that the Controlling Nutritional Status (CONUT) score, calculated using the serum albumin concentration, total peripheral lymphocyte count, and total cholesterol concentration, is a valuable nutritional status index. In the present study, we assessed whether the CONUT score was a significant predictor of complete ulcer healing in patients with critical limb ischemia (CLI). Methods In this retrospective, single center, cohort study, conducted from January 2013 to June 2018, we treated 112 limbs of 89 patients with Fontaine 4 CLI at the Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Japan. The primary endpoint of the study was complete ulcer healing after revascularization, and the secondary endpoint was amputation-free survival (AFS). Results The mean follow-up time was 17.8 months. Complete ulcer healing was achieved during the follow-up period in 91 (81.2%) limbs. The median ulcer healing time was 104 days (range, 16–574 days). In multivariate analysis, improvement of lower skin perfusion pressure ratio of 4) were predictive of incomplete ulcer healing in patients with Fontaine 4 CLI. In addition, the AFS rate was significantly better in patients with a CONUT score ≤4 than in those with a CONUT score >4. Conclusions The CONUT score was associated with postprocedure ulcer healing and long-term limb retention in patients who underwent revascularization. The management of CLI involving ischemic foot ulcers may require ongoing consideration of nutritional status. |
| Databáze: | OpenAIRE |
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