Pulmonary Resection as an Adjunct in the Treatment of Multiple Drug-Resistant Tuberculosis
| Autor: | Marc Van Leuven, Mark de Groot, Ulrich O. von Oppell, P A Willcox, Karen Shean |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Tuberculosis biology business.industry medicine.medical_treatment Incidence (epidemiology) Respiratory disease Retrospective cohort study Perioperative medicine.disease biology.organism_classification Surgery Mycobacterium tuberculosis Pneumonectomy medicine Sputum medicine.symptom business Cardiology and Cardiovascular Medicine |
| Zdroj: | The Annals of Thoracic Surgery. 63:1368-1372 |
| ISSN: | 0003-4975 |
| Popis: | Background. Over the past decade the incidence of pulmonary disease due to drug-resistant strains of Mycobacterium tuberculosis has increased worldwide. We reviewed our local experience to clarify the benefits and risks of pulmonary resection in the management of drug-resistant strains of Mycobacterium tuberculosis . Methods. A retrospective review was performed of 62 patients undergoing pulmonary resection for drugresistant strains of Mycobacterium tuberculosis between January 1990 and November 1995. Results. Fifty-three percent were men and 47% women with an average age of 34 years (range, 16 to 72 years). There was one postoperative death, for a perioperative (30-day) mortality of 1.6%. Sixteen complications occurred in 14 patients for an overall morbidity of 23%. Eighteen of 24 patients (75%) who were persistently sputum positive at the time of operation immediately converted to a negative sputum smear and culture. For all patients who were sputum negative after operation 80% remain relapse-free by actuarial analysis. Conclusions. We believe that operation plays an important ancillary role in the treatment of drug-resistant strains of Mycobacterium tuberculosis . The operation can be performed with acceptable morbidity and mortality and must be combined with appropriate and well-monitored pre- and postoperative antituberculous drug therapy. |
| Databáze: | OpenAIRE |
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