Radiographic, computed tomographic and histopathologic appearance of a presumed spinal chordoma in a dog
| Autor: | Clifford R. Berry, Jocelyn P. Mott, Jeffrey N. Peck, Maron B. Calderwood Mays, Dana Hinton, Anthony Pease |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
Male Pathology medicine.medical_specialty Lower motor neuron lesion Radiography Skeletal neoplasm Myxoid chondrosarcoma Diagnosis Differential Lumbar Dogs medicine Chordoma Animals Humans Dog Diseases Spinal Cord Neoplasms Spinal Chordoma Lumbar Vertebrae General Veterinary business.industry Ferrets Anatomy medicine.disease Spinal cord medicine.anatomical_structure Urinary Incontinence Cats medicine.symptom business Tomography X-Ray Computed Constipation |
| Zdroj: | Veterinary radiologyultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 43(4) |
| ISSN: | 1058-8183 |
| Popis: | A 4-year-old Labrador Retriever presented for urinary incontinence and constipation of 2 weeks duration. There was a tender abdomen, lumbar pain and conscious proprioceptive deficits in both pelvic limbs. Depressed pelvic limb reflexes were present consistent with a lower motor neuron lesion. In radiographs of the lumbar spine there was narrowing of the intervertebral disc space at L5-L6 with irregular, multifocal areas of mineralized opacities dorsal to the intervertebral disc space, presumably within the vertebral canal. On computed tomography, an intramedullary, partially mineralized mass was identified in the spinal cord at the level of caudal L5 through cranial L6. At necropsy there was a four-centimeter enlarged, irregular segment of spinal cord at the level of L5-L6. When sectioned, the spinal cord bad a mineralized texture. Histologically there were variable sized cells that were stellate in appearance with vacuolated cytoplasm (physaliferous cells) and mucinous background consistent with a chordoma. Chordoma is a rare, skeletal neoplasm that originates from mesoderm-derived notochord and has been reported in humans and animals. Extraskeletal development of a chordoma within the spinal cord is a rare manifestation of this neoplasm. However, based on other reports in dogs, solitary extraskeletal locations of chordomas may be the typical expression of this neoplasm in the dog. Differentiation of similar histologically appearing tumors, such as a parachordoma or myxoid chondrosarcoma, will require immunohistochemical characterization of these tumors in veterinary patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text