Diuretics and Bioimpedance-Measured Fluid Spaces in Hypertensive Patients
| Autor: | István Barna, Mária Faludi, Tibor Fülöp, Mihály Tapolyai, Tibor Szarvas, Klára Berta, Zsolt Lengvárszky, Neville R. Dossabhoy |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Intracellular Fluid Endocrinology Diabetes and Metabolism medicine.medical_treatment Body water Cohort Studies Internal medicine Extracellular fluid Internal Medicine medicine Humans Diuretics Aged Retrospective Studies business.industry Retrospective cohort study Middle Aged Original Papers Body Fluids Endocrinology Bioimpedance Analysis Renal abnormalities Hypertension Cohort Linear Models Cardiology Female Diuretic Cardiology and Cardiovascular Medicine business |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.12428 |
| Popis: | The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs. 2.9%; P=.21). The total body water did not differ in the two groups (41.8 L vs. 40.5 L; P=.64). Extracellular fluid volume (ECV) (19.7 L vs. 18.5 L; P=.35) and intracellular fluid volume (ICV) spaces (20.8 L vs. 21.3 L; P=.75) were also not significantly different in the two groups. The ratio of ICV:ECV, however, appeared different: 1.05 vs 1.15 (P=.017) and the effect was maintained in the linear regression-adjusted model (β coefficient: -0.143; P=.001). The diuretic-related distortion of ICV:ECV ratio indicates potential fluid redistribution in hypertensive patients, with ICV participating in the process. |
| Databáze: | OpenAIRE |
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