The elderly patient with surgically resected non-small cell lung cancer — A distinct situation?
| Autor: | Michael Fiegl, Christian Waldthaler, Richard Stockinger, Wilhelm Oberaigner, Johannes Bodner, William Sterlacci, Alexandar Tzankov, Wolfgang Hilbe, Thomas Schmid |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Oncology Surgical resection Aging medicine.medical_specialty Lung Neoplasms Disease Biochemistry Young Adult Endocrinology Recurrence Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor Genetics medicine Humans Stage (cooking) Lung cancer Molecular Biology Aged Neoplasm Staging Aged 80 and over Performance status business.industry Smoking Age Factors Cancer Cell Differentiation Histology Cell Biology Middle Aged Prognosis medicine.disease Surgery Ki-67 Antigen Treatment Outcome Female Non small cell Epidemiologic Methods business |
| Zdroj: | Experimental Gerontology. 47:237-242 |
| ISSN: | 0531-5565 |
| Popis: | The worldwide population shift towards older ages will inevitably lead to more elderly patients being diagnosed with cancer. Lung cancer is the number one cause for cancer mortality and surgical resection is the treatment of choice whenever possible. This study investigates whether elderly patients with non-small cell lung cancer (NSCLC) are characterized by distinct clinical and pathologic features and different clinical course after resection. Special emphasis is placed on disease recurrence, which is an important, but rarely described parameter for biological tumor behavior. Sex, stage, histology, differentiation grade, smoking status, performance status, hemoglobin, C-reactive protein, lactate dehydrogenase, Ki-67 index, recurrent disease and overall survival were analyzed in 383 surgically resected NSCLC patients. Calculations were performed comparing patients70 to ≥70 years. A postoperative follow-up period of 15 years enabled detailed correlations. Rate of disease recurrence and disease-free survival did not differ between any age groups and was not influenced by clinico-pathologic parameters. Elderly patients with a Ki-67 index of3% were associated with significantly decreased overall survival time when compared to younger patients (36.3 and 47.3 months respectively, p=0.029). The biological behavior of NSCLC as reflected by characteristics of disease recurrence is similar for surgically resected patients among different age groups and does not warrant specific recommendations for the elderly surgical patient. The Ki-67 index offers prognostic information for overall survival in the elderly. |
| Databáze: | OpenAIRE |
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