Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
| Autor: | Thomas Henzler, Mathias Meyer, Teresa Floss, Tanja Gaa, Sonja Sudarski, Stefan O. Schoenberg, Ulrike I. Attenberger, Holger Haubenreisser |
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| Rok vydání: | 2018 |
| Předmět: |
Reproducibility
Multidisciplinary business.industry Colorectal cancer Science Blood volume Blood flow medicine.disease Effective dose (radiation) 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Statistical significance Medicine Dual source business Nuclear medicine Perfusion |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-25307-w |
| Popis: | To compare in patients with untreated rectal cancer quantitative perfusion parameters calculated from 3rd-generation dual-source dynamic volume perfusion CT (dVPCT) with 3-Tesla-MR-perfusion with regard to data variability and tumour differentiation. In MR-perfusion, plasma flow (PF), plasma volume (PV) and mean transit time (MTT) were assessed in two measurements (M1 and M2) by the same reader. In dVPCT, blood flow (BF), blood volume (BV), MTT and permeability (PERM) were assessed respectively. CT dose values were calculated. 20 patients (60 ± 13 years) were analysed. Intra-individual and intra-reader variability of duplicate MR-perfusion measurements was higher compared to duplicate dVPCT measurements. dVPCT-derived BF, BV and PERM could differentiate between tumour and normal rectal wall (significance level for M1 and M2, respectively, regarding BF: p rd-generation dual-source CT dVPCT could be included in a standard CT-staging without exceeding national dose reference values. |
| Databáze: | OpenAIRE |
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