The t(8;14)(q24.1;q32) and its variant translocations: A study of 34 cases
| Autor: | Meenu Angi, B. Poonkuzhali, Vandana Kamath, Aby Abraham, Biju George, Sukesh C. Nair, Vikram Mathews, Alok Srivastava, Fouzia Na, J. Meena, Marie Therese Manipadam, Abhijeet Ganapule, Usha Sitaram, Auro Viswabandya, Vivi M. Srivastava, S Yuvarani |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Monosomy Chromosomal translocation lcsh:RC254-282 Translocation Genetic 03 medical and health sciences 0302 clinical medicine Immunophenotyping Internal medicine hemic and lymphatic diseases medicine Humans Hematology business.industry lcsh:RC633-647.5 Karyotype General Medicine Gene rearrangement lcsh:Diseases of the blood and blood-forming organs medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Burkitt Lymphoma Lymphoma Leukemia 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female business |
| Zdroj: | Hematology/Oncology and Stem Cell Therapy, Vol 10, Iss 3, Pp 126-134 (2017) |
| ISSN: | 2589-0646 |
| Popis: | Background: The t(8;14)(q24.1;q32) and its variants – the t(2;8)(p12;q24.1) and t(8;22)(q24.1;q11.2) are associated with B-cell neoplasia and result in MYC/immunoglobulin (IG) gene rearrangement. Patients and methods: We correlated the cytogenetic, molecular and clinico-pathological findings of patients with 8q24 translocations seen in the Department of Haematology, Christian Medical College, Vellore, from January 2003 to December 2015. Results: There were 34 patients with 8q24 translocations (31, ALL and three myeloma). The t(8;14) was seen in 25 patients, t(8;22) in seven and t(2;8) in two. The salient findings were as follows: 85% males; 79% adults, median age 37 years; L3 morphology in 61%; mature B immunophenotype in 77%; extra-medullary disease in 41%; additional abnormalities in 28 (85%), notably, structural abnormalities of chromosome 1q (41%) and 13q (9%) and monosomy 13 (15%); complex karyotypes in 68%.There were two double-hit lymphoma/leukemia, one with a t(14;18)(q32;q21) and the other with a t(3;14)(q27;q11.2), associated with nodal high grade B cell lymphoma and dermal leukemic infiltrates respectively.Only 13 samples were processed for DNA PCR and all these samples were positive for MYC-IgH (c-gamma type) rearrangement. Only in one patient, in addition to c-gamma, c-alpha rearrangement was also detected. Conclusion: The frequency (1.7%) and distribution of these translocations in our series and the association with 1q and 13q abnormalities is similar to the literature. Trisomies 7 and 12 were seen in less than 10% of our patients. Keywords: 8q24 translocations, Burkitt leukemia/lymphoma, Complex karyotype, Double-hit leukemia/lymphoma, MYC/immunoglobulin gene rearrangement |
| Databáze: | OpenAIRE |
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