Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis
| Autor: | Qing Ju, Wenze Tang, Jian Zhang, Jing Cao, Kai Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Poor prognosis Gastroenterology Diagnosis Differential 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Serum biomarkers Internal medicine medicine Humans Pulmonary Surfactant-Associated Protein A business.industry Disease progression General Medicine respiratory system Prognosis Pulmonary Surfactant-Associated Protein D idiopathic pulmonary fibrosis medicine.disease respiratory tract diseases meta-analysis surfactant protein-A 030228 respiratory system 030220 oncology & carcinogenesis Meta-analysis surfactant protein-D ComputingMethodologies_DOCUMENTANDTEXTPROCESSING business Biomarkers Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| Popis: | Supplemental Digital Content is available in the text Background and objective: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Methods: Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers. Standard mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the difference in serum levels of SP-A/D among patients with IPF, when compared to patients with non-IPF interstitial lung disease (ILD), pulmonary infection, and healthy control. Hazard ratio (HR) and 95% CI were used to compare the relative risk of mortality. Results: Twenty-one articles (totalling 1289 IPF patients) were included in final meta-analysis. Serum SP-A levels were significantly higher in patients with IPF than in patients with non-IPF ILD (SMD: 1.108 [0.584, 1.632], P |
| Databáze: | OpenAIRE |
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