Diagnostic dilemma of paraneoplastic arthritis: case series
| Autor: | Yavuz Pehlivan, Kenan Aksu, Mehmet Soy, Ediz Dalkilic, Hakan Emmungil, Sema Yilmaz, Bunyamin Kisacik, Sedat Yilmaz, Fatma Alibaz Öner, Şule Yaşar Bilge, Haner Direskeneli, Veli Cobankara, Seval Kul, Ömer Nuri Pamuk, Rıdvan Mercan, Soner Senel, Ayten Yazici, Ahmet Mesut Onat, Mehmet Akif Ozturk, Hakan Erdem, Salim Dönmez, Şükran Erten, Cemal Bes, Mehmet Sayarlioglu, Timuçin Kaşifoğlu, Gozde Yildirim Cetin |
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| Přispěvatelé: | [Kisacik, Bunyamin -- Onat, Ahmet M. -- Pehlivan, Yavuz -- Kul, Seval] Gaziantep Univ, Fac Med, Div Rheumatol, Dept Internal Med, TR-27100 Sahinbey, Gaziantep, Turkey -- [Kasifoglu, Timucin -- Bilge, Sule Y.] Osmangazi Univ, Fac Med, Eskisehir, Turkey -- [Pamuk, Omer N. -- Donmez, Salim] Trakya Univ, Fac Med, Edirne, Turkey -- [Dalkilic, Ediz] Uludag Univ, Fac Med, Bursa, Turkey -- [Yilmaz, Sedat -- Erdem, Hakan] Gulhane Mil Med Acad, Ankara, Turkey -- [Mercan, Ridvan -- Ozturk, Mehmet A.] Gazi Univ, Fac Med, Ankara, Turkey -- [Bes, Cemal -- Soy, Mehmet] AbantIzzetBaysal Univ Med, Bolu, Turkey -- [Erten, Sukran] Ataturk Hosp, Minist Hlth, Div Rheumatol, Ankara, Turkey -- [Erten, Sukran] Dept Internal Med, Div Rheumatol, Ankara, Turkey -- [Cobankara, Veli] Pamukkale Univ, Fac Med, Ankara, Turkey -- [Senel, Soner] Cumhuriyet Univ, Fac Med, Denizli, Turkey -- [Oner, Fatma A. -- Direskeneli, Haner] Marmara Univ, Fac Med, Istanbul, Turkey -- [Yilmaz, Sema] Selcuk Univ, Selcuklu Fac Med, Konya, Turkey -- [Yazici, Ayten] Sakarya Res & Training Hosp, Div Rheumatol, Sakarya, Turkey -- [Emmungil, Hakan -- Aksu, Kenan] Ege Univ, Fac Med, Izmir, Turkey -- [Cetin, Gozde Y. -- Sayarlioglu, Mehmet] Kahramanmaras Sutcu Imam Univ, Fac Med, TR-46050 Kahramanmaras, Turkey, mercan, ridvan -- 0000-0003-1537-2192, SOY, MEHMET -- 0000-0003-1710-7018, aksu, kenan -- 0000-0001-8889-2688 |
| Rok vydání: | 2014 |
| Předmět: |
Male
Turkey Paraneoplastic Syndromes early rheumatoid arthritis Arthritis immunology Arthritis Rheumatoid differential diagnosis joint Young adult Oligoarthritis predictive value cyclic citrullinated peptide clinical trial Middle Aged biological marker Treatment Outcome Antirheumatic Agents Polyarthritis Biological Markers Female Adult medicine.medical_specialty Malignancy Early rheumatoid arthritis Peptides Cyclic Diagnosis Differential Rheumatology cyclopeptide blood Predictive Value of Tests Rheumatoid Factor Internal medicine medicine Rheumatoid factor Humans human Aged L-Lactate Dehydrogenase business.industry paraneoplastic arthritis lactate dehydrogenase case control study medicine.disease Paraneoplastic arthritis multicenter study Case-Control Studies Immunology antirheumatic agent pathology Joints business Biomarkers malignancy |
| Zdroj: | International journal of rheumatic diseases. 17(6) |
| ISSN: | 1756-185X 0003-4436 |
| Popis: | WOS: 000344362300007 PubMed ID: 24433553 Objectives: Paraneoplastic arthritis (PA) may mimic rheumatic diseases. While presenting the demographic and laboratory features of the patients diagnosed with PA, this study also aims to provide possible appropriate tools to differentiate the PA cases from early rheumatoid arthritis (ERA). Methods: Sixty-five patients with PA (male/female: 43/22) from 15 different rheumatology clinics and 50 consecutive patients with ERA (male/female: 13/37) fulfilling the 2010 American College of Rheumatology (ACR) criteria for the diagnosis if the RA from Gaziantep Rheumatology Early Arthritis Trial (GREAT) as controls who were diagnosed at least 12 months before, were enrolled into study. Results: Mean ages of the patients with PA and ERA were 50.2 +/- 15.3, and 42.7 +/- 12.3, respectively, and the mean ages of the patients with PA were significantly higher than the ERA. Unlike the ERA patients, in our case series PA was predominantly observed among males. Oligoarthritis was significantly higher in solid tumors in contrast to ERA (P = 0.001). Polyarthritis and symmetric arthritis were significantly higher in the ERA group in contrast to all malignancies (P = 0.001). Rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) positivity were significantly higher in the ERA group (each P = 0.001). Lactic dehydrogenase levels of hematologic malignancies were significantly higher than other groups (each, P = 0.001). Conclusions: ERA patients had more symmetric joint involvement than PA; laboratory markers could be also an alternative where there is high RF and anti-CCP positivity with antibody levels among the ERA patients. Finally, the demographic features can be used as differentiating |
| Databáze: | OpenAIRE |
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