Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation

Autor: Gabriela Fragoso, Konstantinos Gkouvatsos, Annie Calvé, Marzell Buffler, Prem Ponka, Kostas Pantopoulos, Christiane Becker, Klaus Schümann, Carine Fillebeen, Daniel Garcia-Santos, Manuela M. Santos
Rok vydání: 2015
Předmět:
Popis: Dietary iron absorption offsets non-specific iron losses and is crucial for systemic iron balance. Inadequate iron acquisition leads to iron deficiency, a condition associated with anemia, poor pregnancy outcome and impaired cognitive and motor development.1 Heme derived from hemoglobin (Hb) and myoglobin of meat products is an important nutritional iron source.2 It is more bioavailable compared to inorganic iron, although less abundant in mixed diets. Thus, two-thirds of body iron stores are estimated to originate from heme, which accounts for only one-third of total dietary iron content in Western populations.3
Databáze: OpenAIRE